منابع مشابه
Lamellipodial actin branches out
Many cell types, including fi broblasts and epithelial cells, move forward by forming an actin-rich membrane protrusion, called a lamellipodium, at the front of the cell. In the early 1990s, researchers thought that lamellipodial protrusion was driven by the polymerization of linear actin fi laments. In two JCB papers published in 1997 and 1999, however, Tatyana Svitkina and colleagues revealed...
متن کاملActin branches out in yeast
Actin branches out in yeast any of the same proteins control actin polymerization in budding yeast and mammalian cells. But budding yeast researchers—hampered by an emphasis on genetics and an inaccessible yeast cytoplasm dense with ribosomes and glycogen granules—have often lagged behind in providing structural descriptions based on electron microscopy (EM). This has fueled suspicions about wh...
متن کاملActin Dynamics: The Arp2/3 Complex Branches Out
Several new findings point to novel functions for the Arp2/3 complex. The dendritic nucleation model that has been proposed to describe cell extension for locomotion may also be applicable to other actin-based processes.
متن کاملMatthew Welch: The many branches of actin regulation
T he actin cytoskeleton powers a variety of processes, from cell migration to intracellular membrane transport. Pathogens often harness their host's actin network to their own ends, hijacking the cytoskeleton to drive cell entry, survival, and intercellular spread. Matthew Welch studies the many different mechanisms that host cells and pathogens use to initiate actin fi lament assembly at the r...
متن کاملPhospholipid prunes actin branches
Starving tumors eat metabolic enzyme Xia et al. describe a way to force cancer cells to destroy a key metabolic enzyme they need to survive. Autophagy helps cancer cells survive the stressful environment inside a tumor. However, blocking the process doesn’t kill cancer cells, so researchers have been looking for a way to make cells vulnerable to autophagy shutdown. Xia et al. used an ovarian ca...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2014
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm3803